Table 3 Amino acid substitutions in H7N9 virus from the family clusters.

From: Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China

Gene

Amino acid position

H7N9 viral strains

A/Anhui/1/2013

A/Fujian/10/2015

A/Fujian/16/2015

A/Fujian/18/2015

A/Fujian/22/2015

PB2

106

T

A

A

—

—

191

K

E

E

E

E

199

A

—

—

S

S

340

R

K

K

—

—

453

P

—

—

H

H

508

R

—

—

K

K

534

S

—

—

F

—

559

N

T

T

T

T

588

A

V

V

—

—

627

K

—

—

E

—

701

D

—

—

N

N

707

A

S

S

—

—

711

N

—

—

S

S

PB1

209

K

N

N

—

—

213

N

T

T

—

—

398

D

N

N

—

—

PA

100

A

—

—

V

V

262

R

—

—

K

K

272

N

—

—

D

D

343

A

—

—

S

S

394

N

—

—

D

D

419

D

—

—

G

G

561

M

—

—

I

—

HA

46

N

—

—

S

S

109

S

N

N

—

—

134

A

V

V

—

—

177

L

I

I

I

I

225

G

—

—

D

—

299

S

—

—

R

R

387

E

A

A

A

A

490

S

R

R

R

R

497

M

—

—

I

I

NP

237

A

—

—

—

T

NA

16

I

T

T

T

T

46

H

R

R

—

—

114

V

—

—

I

I

212

V

—

—

—

A

245

S

P

P

P

P

251

D

—

—

E

E

308

V

—

—

I

I

325

N

S

S

S

S

405

G

V

—

—

—

M2

24

E

D

D

D

D

27

V

—

—

I

I

NS1

206

S

—

—

C

C

  1. Note. The HA gene was under the H3 numbering system and the NA gene under the N2 numbering system. Other internal genes were numbered from the start codon (M).
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