Figure 5 | Scientific Reports

Figure 5

From: Interactome and reciprocal activation of pathways in topical mesenchymal stem cells and the recipient cerebral cortex following traumatic brain injury

Figure 5

Expression of biomarkers in penumbra cortex in rats with and without MSC treatment after TBI. Effects of MSC topical transplantation on proteolytic neuronal and glial injury biomarker levels in the ipsilateral cortex axonal alphaII-spectrin breakdown product SBDP biomarkers levels at different time points after controlled cortical impact (CCI) injury with or without MSC topical transplant are shown. (A) showed representative blots of spectrin and house-keeping gene loading control (Carbonic anhydrase II, 29 kDa). (B) showed quantification of biomarkers (equalized by CA-II band intensity). GFAP and GFAP-breakdown product GBDP biomarkers levels at different time points after controlled cortical impact (CCI) injury with or without MSC topical transplant were shown (C,D) shows representative blots of GFAP and house-keeping gene (Carbonic anhydrase II, 29 kDa). Quantification of comparison: *higher than naïve group; #MSC + CCI treatment group was different from CCI alone group at same time point (p < 0.05). MSC + CCI vs. CCI group-based ANOVA results were stated in the text.

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