Table 4 The association between genotypes of PICK1 and cognitive function in schizophrenic patients.

From: PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia

Cognitive domain

rs2076369

rs3952

TT

GT

GG

p

AA

AG

GG

p

Summary scorea

45.9 (9.5)

51.0 (10.3)

49.8 (9.8)

0.089

50.3 (10.3)

50.3 (9.6)

48.9 (10.4)

0.607

Global composite scoreb

45.5 (9.4)

51.0 (10.3)

49.8 (9.8)

0.063

50.2 (10.4)

50.3 (9.6)

49.0 (10.4)

0.664

Neurocognitive composite scorec

45.9 (9.3)

51.0 (10.3)

49.8 (9.7)

0.090

50.2 (10.1)

50.4 (9.7)

48.8 (10.6)

0.556

1. Speed of processingd

45.6 (7.6)

51.1 (10.6)

49.8 (9.7)

0.059

49.6 (9.6)

50.6 (10.3)

49.3 (10.0)

0.650

 Category Fluency

45.5 (8.6)

50.8 (10.0)

50.0 (10.1)

0.080

49.9 (9.8)

50.6 (9.6)

48.7 (11.2)

0.484

 Trail Making A

45.6 (10.3)

50.2 (10.3)

49.9 (9.8)

0.952

48.7 (9.7)

50.5 (10.2)

50.9 (1.0)

0.286

 WAISe-III,Digit Symbol Coding

45.8 (6.7)

51.3 (10.9)

49.6 (9.5)

0.051

50.6 (10.0)

50.1 (10.1)

48.9 (9.7)

0.597

2. Attention: CPT-IPf

49.9 (9.6)

49.1 (1.0)

50.7 (10.1)

0.440

50.8 (10.6)

49.6 (9.4)

49.8 (10. 7)

0.655

3. Working Memoryg

45.6 (9.8)

51.5 (10.4)

49.5 (9.6)

0.024

50.0 (10.0)

50. 5 (9.8)

48. 8 (10.5)

0.517

 Backward digit span

46.5 (8.8)

51.1 (10.4)

49.7 (9.8)

0.128

50.0 (10.0)

50.6 (9.8)

48.6 (10.4)

0.446

 WMSh-III-Spatial Span (backward)

45.9 (10.7)

51.5 (10.5)

49.4 (9.4)

0.030

49.9 (10.2)

50.4 (10.1)

49.3 (9.5)

0.782

4. Verbal learning and memory: WMS-III, word listing

48.7 (10.1)

50.5 (9.8)

49.8 (10.2)

0.706

50.8 (1.0)

49.6 (9.9)

49.6 (10.4)

0.604

5. Visual learning and memory: WMS-III, visual reproduction

47.3 (8.5)

50.9 (10.9)

49.7 (9.5)

0.267

50.5 (1.0)

50.3 (10.3)

48.5 (9.3)

0.418

6. Reasoning and problem solving: WISCi-III, Maze

48.8 (10.8)

50.0 (9.9)

50.1 (10.1)

0.837

50.0 (9.4)

50.5 (10.3)

48.8 (10.4)

0.542

7. Social cognition: The managing emotions branch of MSCEITj.

46.0 (9.0)

50.6 (9.5)

50.1 (10.4)

0.154

50.0 (10.6)

49.8 (9.2)

50.7 (10.9)

0.845

  1. All data were standardized to T scores and presented by mean (standard deviation).
  2. According to normality of data, ANOVA was used for all scales. If the result was significant, the post-hoc analysis with Bonferroni test was applied to examine the between-genotype differences (data was shown in the results section).
  3. a Summary score: principal component analysis with varimax rotation showed the 7 domains of cognitive tests can be reduced to one dimension and we calculated the estimated summary score.
  4. b Global composite score: an overall composite T scores that included all 7 domains was calculated by standardizing the sum of T scores.
  5. c Neurocognitive composite score: an overall composite T scores that included all 6 neurocognitive domains, excluding social cognition, was calculated by standardizing the sum of T scores.
  6. d Speed of processing: an overall composite T scores that included all 3 domains (Category fluency, Trail making A, WAIS-III Digit Symbol- coding) was calculated by standardizing the sum of T scores.
  7. e WAIS-III: Wechsler adult intelligence scale-Third Edition.
  8. f CPT-IP: Continuous Performance Test-Identical Pairs (only showed CPT1- d′ value: the d′ value in the first session of CPT).
  9. g Working memory: an overall composite T scores that included all 2 domains (Backward digit span, WMS-III, Spatial span) was calculated by standardizing the sum of T scores.
  10. h WMS-III: Wechsler memory scale-Third Edition.
  11. I WISC-III: Wechsler intelligence scale for children-Third Edition.
  12. j MSCEIT: Mayer-Salovey-Caruso Emotional Intelligence Test.
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