Table 5 Multiple regression model analysis of the effects of genetic polymorphism on cognitive function in schizophrenic patients by general linear model.
From: PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia
Cognitive domain | rs2076369 | rs3952 | |||||
|---|---|---|---|---|---|---|---|
GT vs TT | GT vs GG | TT vs GG | AG vs GG | AG vs AA | GG vs AA | ||
Summary score | β | 5.0 | 0.8 | −4.3 | −0.01 | −1.1 | −1.1 |
95% CI | (0.3, 9.7) | (−1.8, 3.3) | (−9.1, 0.6) | (−3.2, 3.2) | (−3.7, 1.6) | (−4.7, 2.5) | |
p | 0.038 | 0.565 | 0.087 | 0.997 | 0.428 | 0.562 | |
Global composite Score | β | 5.4 | 0.9 | −4.4 | −0.2 | −1.0 | −0.8 |
95% CI | (0.7, 10.1) | (−1.6, 3.5) | (−9.3, 0.4) | (−3.4, 2.9) | (−3.6, 1.7) | (−4.4, 2.9) | |
p | 0.025 | 0.470 | 0.074 | 0.892 | 0.473 | 0.682 | |
Neuro-cognitive composite score | β | 4.8 | 0.7 | −4.1 | 0.2 | −0.8 | −1.0 |
95% CI | (0.1, 9.5) | (−1.8, 3.3) | (−9.0, 0.8) | (−3.0, 3.4) | (−3.5, 1.8) | (−4.6, 2.6) | |
p | 0.046 | 0.569 | 0.102 | 0.914 | 0.540 | 0.585 | |
1. Speed of processing | β | 4.8 | 1.2 | −3.6 | −0.3 | 0.1 | 0.3 |
95% CI | (−0.003, 9.7) | (−1.4, 3.8) | (−8.6, 1.4) | (−3.5, 3.0) | (−2.6, 2.8) | (−3.4, 4.1) | |
p | 0.050 | 0.357 | 0.157 | 0.877 | 0.952 | 0.858 | |
Category Fluency | β | 5.3 | 0.2 | −5.1 | 1.3 | −0.5 | −1.8 |
95% CI | (0.4, 10.2) | (−2.5, 2.8) | (−10.2, −0.03) | (−2.0, 4.6) | (−3.3, 2.3) | (−5.6, 2.0) | |
p | 0.036 | 0.910 | 0.049 | 0.444 | 0.738 | 0.359 | |
Trail Making A | β | −0.7 | 1.3 | 2.0 | −1.7 | 2.1 | 3.8 |
95% CI | (−5.7, 4.2) | (−1.4, 4.0) | (−3.1, 7.2) | (−5.0, 1.7) | (−0.7, 4.9) | (0.03, 7.6) | |
p | 0.773 | 0.334 | 0.433 | 0.321 | 0.132 | 0.048 | |
WAIS-III,Digit Symbol Coding | β | 5.5 | 1.1 | −4.4 | −0.1 | −1.5 | −1.4 |
95% CI | (0.7, 10.2) | (−1.5, 3.7) | (−9.3, 0.5) | (−3.3, 3.1) | (−4.2, 1.2) | (−5.0, 2.3) | |
p | 0.025 | 0.413 | 0.080 | 0.933 | 0.273 | 0.464 | |
2. Attention: CPT-IP | β | 0.3 | −1.7 | −2.0 | 0.2 | −1.7 | −1.9 |
95% CI | (−4.6, 5.2) | (−4.4, 1.0) | (−7.1, 3.1) | (−3.1, 3.5) | (−4.4, 1.1) | (−5.6, 1.9) | |
p | 0.901 | 0.206 | 0.434 | 0.899 | 0.238 | 0.328 | |
3. Working Memory | β | 5.2 | 1.8 | −3.4 | −0.7 | −0.3 | 0.4 |
95% CI | (0.6, 9.7) | (−0.7, 4.2) | (−8.1, 1.3) | (−3.7, 2.4) | (−2.9, 2.3) | (−3.1, 3.8) | |
p | 0.027 | 0.163 | 0.155 | 0.681 | 0.825 | 0.843 | |
Backward digit span | β | 3.9 | 0.9 | −3.0 | 0.4 | −0.2 | −0.6 |
95% CI | (−0.9, 8.6) | (−1.7, 3.4) | (−7.9, 1.9) | (−2.8, 3.6) | (−2.9, 2.5) | (−4.2, 3.1) | |
p | 0.111 | 0.517 | 0.228 | 0. 821 | 0.879 | 0.757 | |
WMS-III-Spatial Span (backward) | β | 5.0 | 2.1 | −2.8 | −1.5 | −0.3 | 1.2 |
95% CI | (0.4, 9.6) | (−0.4, 4.6) | (−7.6, 2.0) | (−4.6, 1.7) | (−2.9, 2.3) | (−2.4, 4.7) | |
p | 0.035 | 0.092 | 0.246 | 0.356 | 0.829 | 0.515 | |
4. Verbal Learning and memory: WMS-III, word listing | β | 1.3 | −0.3 | −1.6 | −0.7 | −1.6 | −0.9 |
95% CI | (−3.3, 5.8) | (−2.8, 2.1) | (−6.3, 3.1) | (−3.7, 2.4) | (−4.1, 1.0) | (−4.4, 2.6) | |
p | 0.583 | 0.801 | 0.507 | 0.660 | 0.229 | 0.618 | |
5. Visual learning and memory: WMS-III, visual reproduction | β | 3.6 | 0.2 | −3.3 | 1.4 | −1.0 | −2.4 |
95% CI | (−1.3, 8.5) | (−2.4, 2.9) | (−8.4, 1.7) | (−1.9, 4.7) | (−3.8, 1.8) | (−6.2, 1.3) | |
p | 0.153 | 0.859 | 0.197 | 0.392 | 0.483 | 0.205 | |
6. Reasoning and problem solving: WISC-III, Maze | β | 2.0 | 0.3 | −1.8 | 1.6 | 0.1 | −1.6 |
95% CI | (−2.6, 6.6) | (−2.2, 2.7) | (−6.5, 3.0) | (−1.5, 4.7) | (−2.5, 2.6) | (−5.1, 2.0) | |
p | 0.388 | 0.845 | 0.464 | 0.307 | 0.972 | 0.384 | |
7. Social cognition: The Managing emotions branch of MSCEIT | β | 5.3 | 1.5 | −3.8 | −2.2 | −1.2 | 1.1 |
95% CI | (0.6, 10.0) | (−1.1, 4.0) | (−8.7, 1.0) | (−5.4, 1.0) | (−3.8, 1.5) | (−2.6, 4.7) | |
p | 0.028 | 0.262 | 0.123 | 0.171 | 0.393 | 0.567 | |
