Figure 2 | Scientific Reports

Figure 2

From: A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation

Figure 2

mGluR sensitization of Mechanical Responses in Nociceptors from AKAP WT and KO mice. (A) Discharge rates of receptive fields of WT nociceptors following mustard oil (MO) application in ascending doses (2 minutes each). *p < 0.05 vs. pre-drug baseline, Kruskal-Wallis ANOVA on Ranks with Dunn’s posthoc analysis. (B) Representative traces from (A,B) AKAP WT and (C,D) KO nociceptor nociceptor field activity in response to 10 µM DHPG (A,C) alone or (B,D) applied with 10 µM MO. (C). Collective drug-induced activity discharge rates of receptive fields from experiments conducted in panel B. *p < 0.05, significant vs. pre-drug; +p < 0.05; significant vs KO at same dose; Kruskal-Wallis ANOVA on Ranks with Dunn’s posthoc analysis.

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