Figure 3 | Scientific Reports

Figure 3

From: A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation

Figure 3

mGluR sensitization of Mustard Oil Responses in Nociceptors from AKAP WT and KO mice. (A) Recorded threshold to activation to a ramp stimulus following exposure to 1 mM or 3 mM DHPG from skin-nerve preparation nociceptor receptive fields of AKAP WT and KO mice and (B). Discharge rates to a suprathreshold mechanical stimulus (250 mN). *p < 0.05; significant vs. pre-drug; +p < 0.05, significant vs. KO at same dose; Kruskal-Wallis ANOVA on Ranks with Dunn’s posthoc analysis.

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