Figure 1 | Scientific Reports

Figure 1

From: Protective effects of APOE e2 against disease progression in subcortical vascular mild cognitive impairment patients: A three-year longitudinal study

Figure 1

Statistical map shows regions where APOE2 carriers had slower rate of cortical thinning compared to APOE3 homozygotes. Compared to the APOE3 homozygotes, APOE2 carriers showed slower cortical thinning in the left dorsolateral frontal, lateral temporal, medial frontal; right lateral parietal, medial temporal; and bilateral inferior temporal areas. Linear mixed effects model was performed using group (APOE genotype), time, age, gender, intracranial volume, and the interaction term between group and time (group-by-time) as fixed effects; and patient as a random effect (uncorrected p < 0.01). Abbreviation: APOE, apolipoprotein E.

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