Table 1 Antimicrobial activities of Hc-CATH and its truncated derivatives.
Peptide | Sequence | MIC (µg/mL) | ||||||
|---|---|---|---|---|---|---|---|---|
E. coli | S. dysenteria | P. mirabilis | P. aeruginosa | S. aureus | B. subtilis | C. albican | ||
Hc-CATH | KFFKRLLKSVRRAVKKFRKKPRLIGLSTLL | 2.34 | 0.59 | 4.69 | 18.75 | 4.69 | 75 | 4.69 |
Hc1 | KFFKRLLKSVRRAVKKFRK [NH2] | 18.75 | 4.69 | 9.38 | 9.38 | 4.69 | 18.75 | 9.38 |
Hc2 | KFFKRLLKSVRRAVKKFR [NH2] | 9.38 | 2.34 | 9.38 | 9.38 | 9.38 | 18.75 | 9.38 |
Hc3 | KFFKRLLKSVRRAVKKF [NH2] | 18.75 | 2.34 | 4.68 | 9.38 | 9.38 | 9.38 | 9.38 |
Hc4 | KFFKRLLKSVRRAVKK [NH2] | 75 | 4.69 | 75 | 150 | 75 | — | 75 |
Hc5 | KFFKRLLKSVRRAVK [NH2] | 37.5 | 4.69 | 18.75 | 75 | 37.5 | 150 | 37.5 |
Hc6 | KFFKRLLKSVRRAV [NH2] | 75 | 18.75 | 37.5 | 150 | 75 | 150 | 75 |
Hc7 | KFFKRLLKSVRRA [NH2] | — | 75 | — | 150 | — | — | — |
Hc8 | FFKRLLKSVRRAVKKFRK [NH2] | 18.75 | 4.69 | 18.75 | 18.75 | — | 37.5 | 9.38 |
Hc9 | FKRLLKSVRRAVKKFRK [NH2] | 150 | 18.75 | — | 150 | 9.38 | — | 150 |
Hc10 | KRLLKSVRRAVKKFRK [NH2] | — | — | — | — | — | — | — |
Hc11 | RLLKSVRRAVKKFRK [NH2] | — | 150 | — | — | — | — | — |
Hc12 | LLKSVRRAVKKFRK [NH2] | — | — | — | — | — | — | — |
Hc13 | LKSVRRAVKKFRK [NH2] | — | — | — | — | — | — | — |
Hc14 | FFKRLLKSVRRAVKKF [NH2] | 18.75 | 4.69 | 9.38 | 37.5 | 9.38 | 37.5 | 150 |
Hc15 | FKRLLKSVRRAVKKF [NH2] | 75 | 37.5 | — | — | — | — | — |
