Table 3 Sequences and physicochemical parameters of the four hybrid peptides.

From: Cathelicidin-trypsin inhibitor loop conjugate represents a promising antibiotic candidate with protease stability

Hybrid peptide

Amino acid sequence (Length)

Mw/pI

Net charge

H3TI

KFFKRLLKSVRRAVKKFCWTKSIPPKPC (28)

3393.25Da/11.21

10

H3TIF

KFFKRFFKSFRRAFKKFCWTKSIPPKPC (28)

3557.37Da/11.21

10

TIH3

CWTKSIPPKPCKFFKRLLKSVRRAVKKF[NH2] (28)

3393.25Da/11.21

10

TIH3F

CWTKSIPPKPCKFFKRFFKSFRRAFKKF[NH2] (28)

3557.37Da/11.21

10

  1. The disulfidebridged hendecapeptide (CWTKSIPPKPC) proteinase inhibitor loop is indicated in italics and bold; the Phe mutations are underlined.
Back to article page