Table 2 Differentially expressed proteins between insulinomas and paired pancreatic issues.
From: Prognostic relevance of UCH-L1 and α-internexin in pancreatic neuroendocrine tumors
Proteins | NCBI accession | Tu/Nor ratio | PI | Mr (kDa) | Sequence Coverage (%) | Function by Gene Ontology Annotation Database | Process involved (experimental evidence) Gene Ontology Annotation Database | |
|---|---|---|---|---|---|---|---|---|
136681 | UCHL-1: Ubiquitin carboxyl-terminal hydrolase isozymeL1 | GI: 21361091 | 55.4 | 5.48 | 24.8 | 72.65 | Ubiquitinbinding; protein binding; cysteine-type endopeptidase activity; omega peptidase activity | Negative regulation of MAP kinase activity; cell Proliferation; ubiquitin-dependent protein catabolic processetc. |
317373388 | MAP1B:Microtubule -associated protein 1B | GI:153945728 | 128.8 | 4.81 | 270.5 | 18.48 | Protein binding; structural molecule activity | Microtubule organization; nervous system development; cellular process etc. |
215274255 | MAP2: Microtubule-associated protein 2 | GI:87578396 | >500 | 4.91 | 199.4 | 15.93 | Dystroglycan, protein, microtubule, tubulin binding; structural molecule activity | Microtubule cytoskeleton organization; microtubule bundle formation; central nervous system neuron development etc. |
2506816 | VCAN: Versican core protein | GI: 21361116 | 54.2 | 4.51 | 372.6 | 5.92 | protein binding | Cell adhesion; multicellular organismal development; central nervous system development; glial cell migration etc. |
1708540 | PDX-1: Pancreas/duodenum homeobox protein 1 | GI:4557673 | >500 | 7.56 | 30.8 | 12.01 | Pranscription factor activity, sequence-specific DNA binding | Negative regulation of transcription from RNA polymerase II promoter; liver development; differentiation of pancreatic β cell; transcription, DNA-templated |
1168867 | CDK4: Cyclin-dependent kinase 4 | GI:49457488 | >500 | 7.01 | 33.7 | 10.89 | Nucleotide, ATP, cyclin, protein complex binding etc. | Protein phosphorylation; circadian rhythm; positive regulation of cell proliferation etc. |
20141266 | INX: Alpha-internexin or NF-66 | GI:14249342 | 33.4 | 5.4 | 55.4 | 18.84 | Structural molecule activity; intermediate filament cytoskeleton, structural constituent of cytoskeleton | Multicellular organismal development; nervous system development; substantial nigra development; cell differentiation; organization |
