Figure 6 | Scientific Reports

Figure 6

From: Interleukin 22 attenuated angiotensin II induced acute lung injury through inhibiting the apoptosis of pulmonary microvascular endothelial cells

Figure 6

IL-22 significantly stimulated phosphorylation at tyrosine 705 of STAT3 in PMVECs. (A) The expression of pY705-STAT3 was up-regulated after IL22 interference, and reached the peak level at 30 min. (B) Immunofluorescence analysis indicated the expression of pY705-STAT3 significantly increased together with accumulation in the nucleus after IL22 interference. (C) The expression of pY705-STAT3 in the AngII+IL22 group was higher than the other groups. The raw data of Western blot were listed in the Supplementary file. *P < 0.05 versus control group; #P < 0.05 versus AngII group and AngII+IL-22+AG490 group.

Back to article page