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Figure 2

From: Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model

Figure 2

FluoroGold labeling of RGCs in normal and glaucomatous retinas. (A–D) FluoroGold labeling of surviving RGCs in flat-mounted retinas 3 weeks after inducing ocular hypertension. The left panels in A–D were photographed at low magnification (scale bar, 2 mm). Enlarged images (scale bar, 50 μm) from the same retinas are shown in the central (middle) and peripheral (right) panels. PNU-282987 increased RGC viability and preserved cellular integrity (D) relative to the vehicle (C). (E,F) Quantitative analysis of RGC survival in control eyes, ocular hypertension eyes with or without the vehicle and PNU-282987-treated ocular hypertension eyes (n = 10). *p < 0.05, **p < 0.01, and ***p < 0.001 (one-way analysis of variance). The results are expressed as the mean ± SE. OHT, ocular hypertension; RGC, retinal ganglion cell.

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