Table 2 pEC50 values of S1P derivatives at S1P receptors.

From: Ligand chain length drives activation of lipid G protein-coupled receptors

 

C16

C17

S1P

C19

C20

S1P1 (n = 4)

6.5 ± 0.3

6.9 ± 0.2

7.1 ± 0.3

6.6 ± 0.2

n.r.

S1P2 1 (n = 4)

6.9 ± 0.1

7.0 ± 0.1

7.5 ± 0.0

6.7 ± 0.1

6.3 ± 0.1

S1P2 2 (n = 3)

6.5 ± 0.2

7.1 ± 0.1

7.3 ± 0.2

6.5 ± 0.2

6.0 ± 0.2

S1P4 (n = 4)

7.3 ± 0.2

7.1 ± 0.1

7.0 ± 0.1

6.1 ± 0.1

5.6 ± 0.1

S1P5 (n = 2)

7.4 ± 0.2

6.9 ± 0.1

7.3 ± 0.5

6.7 ± 0.1

n.r.

  1. The experimental EC50 for all S1P derivatives were determined from the dose-response curves of the aequorin-based functional assays. Mean values of pEC50 (negative logarithm of EC50) on 2 to 4 independent experiments are presented along with the corresponding S.E.M. values.
  2. 1S1P5 cells, 2CHO-Aeq cells, n.r. = not reliable.
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