Figure 3 | Scientific Reports

Figure 3

From: Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders

Figure 3

Characterization of the serotonin-melatonin pathway in autopsy-derived ileum samples from 13 individuals with ASD and 11 controls. (a) Example of chromogranin A immunostaining in one sample from a patient with ASD, assessing the presence of enterochromaffin cells. (b) Serotonin content. (c) NAS content. (d) Melatonin content. (e) AANAT activity. (f) Correlation between NAS content and AANAT activity (regression after log transformation of NAS). (g) Correlation between melatonin content and AANAT activity. (h) ASMT activity. (i) Correlation between NAS content and ASMT activity (regression after log transformation of NAS). (j) Correlation between melatonin content and ASMT activity. (k) Contour plot of NAS content, AANAT and ASMT activities in patient (red dots) and control (green dots) samples. (l) Contour plot of melatonin content, AANAT and ASMT activities in patients (red dots) and control (green dots) samples. The ASD group was compared to the control group using Wilcoxon two-sample test. Boxes indicate medians and quartiles.

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