Figure 2 | Scientific Reports

Figure 2

From: Functional interaction between FUS and SMN underlies SMA-like splicing changes in wild-type hFUS mice

Figure 2

hFUS+/+ mice show decreased number of mature snRNPs. (a) Lumbar spinal cords from hFUS−/− and hFUS+/+ mice (40 days) were stained with the Y12 antibody to detect Sm proteins and with an anti-ChAT antibody to detect motor neurons. Magnifications are show to highlight the presence of Y12-positive nuclear dots (arrows) corresponding to mature snRNPs. Scale bar: 20 μm. (b) Distribution of motor neurons (%) classified according to the number of Y12-positive (Y12+) snRNPs per nucleus. (c) Mature snRNPs per motor neuron were scored and the means ± SD are reported. At least 100 motor neurons for each genotype were counted.

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