Figure 5
Disease progression in hFUS+/+ mice is not influenced by SMN depletion. (a) The indicated mice were subjected to a Rotarod analysis once a week starting from 13 weeks and for the following 23 weeks. At least 15 animals for each genotype were used. Results were plotted as mean ± SE. (b) Mice with the indicated genotypes were weighted weekly starting from 1 week of age. Approximately 5 animals for each genotype were monitored. The average weight ± SD is shown. (c) Mice were subjected to grip test analysis for the indicated time frame. The age (days) when animals failed the test were considered the onset of grip deficits and analysed with Kaplan-Meier analysis. Statistical analysis reveals an average onset of grip deficits at 35 ± 4 days for hFUS+/+; Smn+/+ mice and at 35 ± 3 days for hFUS+/+; Smn+/− mice. (d) Kaplan-Meier analysis of cumulative survival of mice with the indicated genotypes. Log–rank test was used to compare hFUS+/+; Smn+/− and hFUS+/+; Smn+/+ animals. At least 30 animals for each genotype were scored, except for the hFUS+/+; Smn+/−, where 17 animals were used. Statistical analysis of cumulative survival reveals an average survival time of 40.2 ± 5.8 days for hFUS+/+; Smn+/+ mice and 40.6 ± 5.3 days for hFUS+/+; Smn+/− mice.
