Table 1 Top 20 significantly up- or down-regulated MAM proteins in diabetes.

1

H2A1F_MOUSE

Hist1h2af

5

Histone H2A type 1-F

5.34

0.0385

2

H4_MOUSE

H4-53

7

Histone H4

4.85

0.0398

3

H2B1B_MOUSE

Hist1h2bb

6

Histone H2B type 1-B

4.10

0.0330

4

H31, H32, H33, H3C _MOUSE

H3.1;H3.2 -615; H3.3

2

Histone H3.1, H3.2, H3.3, H3.3 C

3.84

0.0496

5

CAD13_MOUSE

Cdh13

2

Cadherin-13

3.36

0.0036

6

CNRP1_MOUSE

Cnrip1

4

CB1 cannabinoid receptor-interacting protein 1

2.23

0.0024

7

K1C10_MOUSE

Krt10

4

Keratin, type I cytoskeletal 10

2.19

0.0166

—8

TBC24_MOUSE

Tbc1d24

5

TBC1 domain family member 24

2.10

0.0013

9

H10_MOUSE

H1f0

2

Histone H1.0

2.04

0.0304

10

ACBP_MOUSE

Dbi

3

Acyl-CoA-binding protein

2.04

0.0098

11

MOBP_MOUSE

Mobp

2

Myelin-associated oligodendrocyte basic protein

2.03

0.0331

12

HINT1_MOUSE

Hint1

2

Protein kinase C inhibitor 1

1.91

0.0275

13

LAT1_MOUSE

Slc7a5

3

Large neutral amino acids transporter small subunit1

1.89

0.0002

14

SYNE2_MOUSE

Syne2

1

Synaptic nuclear envelope protein 2, Nesprin-2

1.81

0.0369

15

RAB12_MOUSE

Rab12

2

Ras-related protein Rab-12

1.80

0.0465

16

CLD11_MOUSE

Cldn11

4

Claudin-11

1.78

0.0185

17

NOE1_MOUSE

Noe1

1

Noelin (Neuronal olfactomedin-related ER localized protein)

1.77

0.0001

18

MRP_MOUSE

Marcksl1

2

MARCKS-related protein

1.77

0.0169

19

PCSK1_MOUSE

Pcsk1n

5

ProSAAS (IA-4)

1.72

0.0027

20

ERP29_MOUSE

ERp29

5

Endoplasmic reticulum resident protein 29

1.70

0.0161

1

AZI1_MOUSE

Cep131

1

Centrosomal protein of 131 kDa

0.14

0.0128

2

P2Y12_MOUSE

P2ry12

3

P2Y purinoceptor 12

0.34

0.0012

3

SKP1_MOUSE

Skp1

6

S-phase kinase-associated protein 1

0.46

0.0091

4

COPB2_MOUSE

Copb2

1

Coatomer subunit beta’ (Beta’-coat protein)

0.47

0.0000

5

DIRC2_MOUSE

Dirc2

2

Disrupted in renal carcinoma protein 2 homolog

0.52

0.0407

6

PPT1_MOUSE

Ppt1

5

Palmitoyl-protein thioesterase 1

0.54

0.0002

7

CHM4B_MOUSE

Chmp4b

4

Charged multivesicular body protein 4b

0.55

0.0004

8

CRYAB_MOUSE

Cryab

6

Alpha-crystallin B chain

0.58

0.0319

9

COPD_MOUSE

Arcn1

3

Coatomer subunit delta

0.58

0.0001

10

ITB2_MOUSE

Itgb2

4

Integrin beta-2

0.59

0.0013

11

PP2AA_MOUSE

Ppp2ca

5

Serine/threonine-proteinphosphatase2Acatalytic subunit alpha

0.61

0.0076

12

DAB2_MOUSE

Doc2

2

Disabled homolog 2 (DOC-2)

0.63

0.0102

13

SE6L2_MOUSE

Sez6l2

3

Seizure 6-like protein 2

0.63

0.0234

14

ACLY_MOUSE

Acly

11

ATP-citrate synthase

0.63

0.0000

15

CNR1_MOUSE

Cnr1

2

Cannabinoid receptor 1

0.64

0.0054

16

COPA_MOUSE

Copa

6

Coatomer subunit alpha

0.64

0.0001

17

KPCG_MOUSE

Prkcg

20

Protein kinase C gamma type

0.65

0.0075

18

ITAM_MOUSE

Itgam

2

Integrin alpha-M

0.65

0.0062

19

ALBU_MOUSE

Alb

5

Serum albumin

0.66

0.0118

20

DOCK7_MOUSE

Dock7

2

Dedicator of cytokinesis protein 7

0.66

0.0230