Figure 6
The excitatory effect of SNP was abolished in TRPV1−/− mice. (a) Representative spontaneous afferent discharge recordings of response to SNP (0.16 mM) on mice. The upper trace shows the raw recording of whole nerve discharge, the middle trace is the number of nerve discharge in 3 s, and the lower trace shows corresponding intraluminal pressure. The arrows indicate the administration of SNP (0.16 mM). SNP increased the afferent discharge of wild type C57BL6/J mice, but failed to increase the nerve firing of TRPV1−/− mice. (b) Summary values showing that the TRPV1 genetic deletion eliminated the excitatory effect of SNP (0.16 mM). n = 6 in each group, ***P < 0.001 vs wild type C57BL6/J group, Students’ t-test.
