Figure 4
From: Aβ42 pentamers/hexamers are the smallest detectable oligomers in solution
Results from SANS scattering experiments after incubation of Aβ42 at pH 7.4. Measurement and incubation was in 50 mM Napi plus 150 mM NaCl in 100% D2O at 7 °C. (a) Exemplary SANS scattering intensity after 0.5 h. Contributions to the scattered intensity arise from aggregates larger than 50 nm resulting in a power law (black broken line), mid-size aggregates modelled as ellipsoid of revolution (blue broken line) and small oligomers (orange broken line), which are modelled by a Beaucage function. A vanishing background of monomers is modelled as a Beaucage function with fixed R g = 1 nm. The combined fit result is shown as a black solid line. Ellipsoids have radii between 50 and 10 nm. (b) The radius of gyration of small oligomers from SANS analysis after incubation at concentrations of 221 μM (black), 55 µM (blue) and 22 µM (green).
