Figure 1 | Scientific Reports

Figure 1

From: Fluorescence correlation spectroscopy reveals a cooperative unfolding of monomeric amyloid-β 42 with a low Gibbs free energy

Figure 1

Normalized correlation curves (○) with their corresponding best-fit lines (−) of AF488-C(0)Aβ42 under denaturing conditions of increasing GdnHCl concentrations and based on a one-component diffusion model (equation (S1) in the Supplementary Information). The shift towards larger correlation times can mainly be attributed to (i) the increasing viscosity of the GdnHCl solutions and (ii) an increase of the hydrodynamic radius due to the unfolding process.

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