Figure 1

MB is a more potent ROS scavenger than NAC, MitoQ and mTEM. (A) Comparison of mitochondrial specific superoxide (MitoSOX) levels in normal and HGPS fibroblasts treated with vehicle, 100 nM MB or 100 μM NAC for four weeks. (B) Growth curves of normal and HGPS fibroblasts during the four-week treatment with vehicle, 100 nM MB or 100 μM NAC. (C) Comparison of MitoSox levels in normal and HGPS fibroblasts treated with vehicle, 100 nM MB or 100 nM MitoQ for four weeks. (D) Growth curves of normal and HGPS fibroblasts during the four-week treatment with vehicle, 100 nM MB or 100 nM MitoQ. (E) Comparison of MitoSox levels in normal and HGPS fibroblasts treated with vehicle, 100 nM MB or 100 nM mTEM for four weeks. (F) Growth curves of normal and HGPS fibroblasts during the four-week treatment with vehicle, 100 nM MB or 100 nM mTEM. (*p < 0.05, **p < 0.01).