Figure 2 | Scientific Reports

Figure 2

From: Therapeutic effects of matrine derivate MASM in mice with collagen-induced arthritis and on fibroblast-like synoviocytes

Figure 2

Effects of MASM administration on histopathological abnormalities and the production of pro-inflammatory cytokines in mice with CIA. (A) Hematoxylin and eosin (H&E) staining of the hind paws from the indicated different four groups. Original magnification x100. (B) Local tumor necrosis α (TNF-α) expression in the hind paws tissues was measured by immunohistological staining. Original magnification x100 and x200. (C) Pathological scores determined as described in Materials and Methods. (D) The serum levels of TNF-α, IL-1β and IL-6 were assessed by specific enzyme-linked immunosorbent assay (Elisa). Bars show the mean ± SEM (n = 10–15 mice per group). #P < 0.01 compared with normal group. *P < 0.05, **P < 0.01 versus the control group.

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