Figure 4 | Scientific Reports

Figure 4

From: The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites

Figure 4

K13-mediated ART resistance is associated with a higher proportion of DP-rings. (A) Prevalence of viable DP-rings detected in K13 mutant Dd2 transgenic and Dd2-WT parasites following six hours of exposure to 700 nM DHA. Growth was measured at day one and survival normalized to DMSO-treated control parasites. (B) DP-rings susceptibility in K13 mutant Dd2 transgenic and Dd2-WT parasites exposed to KDU691 (1.4 µM) and measured at day four. Data are from three biological experiments and three technical replicates each (means ± SEM % growth). Percent growth was measured by HCI using MitoTracker® Orange relative to DMSO.

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