Figure 1
From: Kinetic interpretation of log-logistic dose-time response curves
(a) Schematic representation of time-response curves, showing the temporal evolution of a measurable property P (e.g. mortality in biological systems) following the logistic curve for different active agent dose levels. The concentration or dose level either increases or decreases in the order: a < b < c < d. The magnitude of the property ranges from P o at zero transformation to P ∞ at complete transformation (or conversion). The property of central interest is the time t m where the transformation equals the median effect value P m = (P ∞ − P o )/2. (b) Dose response curve for a fixed elapsed treatment time derived from the set of time-response curves. The median response is attained at a dosage equivalent to LC 50.
