Figure 4 | Scientific Reports

Figure 4

From: Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice

Figure 4

Micro-CT data display evidence of significantly increased bone mass of subchondral bone of knee joint in Cre negative mice with DMM surgery compared with Cre negative mice with sham surgery, and the increased bone mass was significantly reduced in Runx2 Agc1CreER KO mice. All the mice were administrated tamoxifen at 2-months of age, followed by the DMM surgery performed at 3-months of age. Mice were sacrificed 3 months after surgery. (*P < 0.05, **P < 0.01, one-way ANOVA followed by Tukey’s post-hoc test; n = 6–8 mice per group).

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