Figure 4

LPS induced inflammatory mediators in hepatocytes of Ptpn6 ^H-KO mice. Production of (A) TNF-α, (B) IL-1β, (C) IL-6 and (D) Nitric oxide by hepatocytes isolated from Ptpn6 ^H-KO and Ptpn6 ^f/f mice after LPS stimulation (1 μg/ml). Data are presented as mean ± SEM of three samples in three independent experiments. Production of (E) TNF-α, (F) IL-1β, (G) IL-6 and (H) nitric oxide by peritoneal macrophages isolated from Ptpn6 ^H-KO and Ptpn6 ^f/f mice after LPS stimulation (1 μg/ml). Data are presented as mean ± SEM of three samples in three independent experiments. *P ≤ 0.05, **P ≤ 0.01 and ***P ≤ 0.001.