Figure 4
ArtABs induce the upregulation of intracellular cAMP levels in murine macrophage-like cells. (A–G) cAMP accumulation in RAW 264.7 cells treated with different amounts of ArtAB in the presence of isoproterenol (ISO) and/or LPA. Cells were incubated with ArtABs at the indicated concentrations for 18 h, and then treated with 10 mM ISO and 50 mM LPA at 37 °C for 15 min. Error bars indicate are the standard errors of the means (SEM). Data are from three separate experiments. Values with the same letter are not significantly different (P < 0.05, one-way analysis of variance and Tukey’s test).
