Table 5 Sensitivity analysis: Body mass index and death at 12 months, death or high dependency at 3 and 12 months.

From: Association of body mass index with mortality and functional outcome after acute ischemic stroke

 

Death at 12 months

Death or high dependency at 3 months

Death or high dependency at 12 months

HR (95% CI)

OR (95% CI)

OR (95% CI)

Sensitivity analysis 1

 Underweight

1.63 (1.21–2.19)

1.46 (1.09–1.96)

1.46 (1.09–1.96)

 Overweight

0.95 (0.76–1.18)

0.96 (0.82–1.13)

1.00 (0.85–1.18)

 Obese

1.01 (0.62–1.66)

0.70 (0.48–1.01)

0.84 (0.58–1.22)

Sensitivity analysis 2

 Underweight

1.58 (1.16–2.15)

1.46 (1.08–1.97)

1.40 (1.03–1.90)

 Overweight

0.96 (0.77–1.20)

0.93 (0.79–1.09)

0.95 (0.80–1.12)

 Obese

0.97 (0.69–1.38)

0.93 (0.72–1.19)

1.05 (0.81–1.35)

Sensitivity analysis 3

 Underweight

1.64 (1.22–2.22)

1.46 (1.04–2.03)

1.88 (1.37–2.59)

 Overweight

0.97 (0.78–1.20)

0.98 (0.81–1.18)

0.99 (0.82–1.20)

 Obese

1.07 (0.78–1.48)

0.99 (0.74–1.32)

1.11 (0.83–1.47)

Sensitivity analysis 4

Current smoker

 Underweight

2.01 (0.96–4.19)

1.37 (0.77–2.45)

0.98 (0.52–1.82)

 Overweight

0.87 (0.51–1.49)

0.82 (0.60–1.12)

0.96 (0.70–1.33)

 Obese

0.89 (0.34–2.36)

0.99 (0.59–1.68)

0.98 (0.56–1.72)

Current non-smoker

 Underweight

1.58 (1.13–2.20)

1.43 (1.01–2.02)

1.58 (1.12–2.24)

 Overweight

0.97 (0.76–1.22)

0.96 (0.80–1.15)

0.94 (0.78–1.13)

 Obese

1.11 (0.79–1.57)

0.94 (0.71–1.23)

1.07 (0.81–1.41)

  1. CI, confidence interval; HR, hazard ratio; OR, odds ratio. The normal-weight group was the reference group. Sensitivity analysis 1 used the World Health Organization BMI criteria, which included 282 underweight patients (BMI < 18.5 kg/m2), 2889 normal-weight patients (BMI 18.5 to <25 kg/m2), 1408 overweight patients (BMI 25 to < 30 kg/m2) and 203 obese patients (BMI ≥ 30 kg/m2). Sensitivity analysis 2 excluded 234 patients who had received thrombolysis treatment, leaving 274 underweight patients, 2210 normal-weight patients, 1579 overweight patients and 485 obese patients in the analysis. Sensitivity analysis 3 redefined high dependency as a modified Rankin scale score of 4–5. Sensitivity analysis 4 was a stratified analysis according to smoking status (current smoker and current non-smoker). In 1375 patients of current smoker, there were 76 underweight patients, 670 normal-weight patients, 509 overweight patients and 120 obese patients. In 3407 patients of current non-smoker, there were 206 underweight patients, 1636 normal-weight patients, 1168 overweight patients and 397 obese patients.
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