Table 1 Pooled risk ratio estimates for overall and disease-free survival by presence or absence of extranodal extension.
Parameter | N. of studies | No. of events in ENE+ | No. of ENE+ | No. of events in ENE− | No. of ENE− | Risk ratio (95% CI) | P-value | Heterogeneity | Egger’s bias test; p-value | Trim and fill [trimmed] |
|---|---|---|---|---|---|---|---|---|---|---|
ACM | 1 | 20 | 71 | 5 | 31 | 1.75 (0.72–4.23) | 0.22 | — | — | — |
CSM | 4 | 97 | 312 | 51 | 198 | 1.21 (0.98–1.50) | 0.08 | I2 = 0 | 0.87; 0.30 | 1.18 (0.94–1.50)1 |
ROR | 3 | 248 | 477 | 163 | 321 | 1.15 (1.04–1.28) | 0.008 | I2 = 0 | 0.29; 0.87 | Unchanged |
