Figure 2
From: Effects of Protein Corona on IAPP Amyloid Aggregation, Fibril Remodelling, and Cytotoxicity
Viability of HUVECs exposed to 25 μM IAPP and amyloids in the presence of α-lactalbumin (aLac) and lysozyme (Lys) after 24 h. (A) Bright-field images reveal extensive cell death in the presence of IAPP, and some loss of cells with IAPP amyloids. (B) The calcein-AM viability assay demonstrates high toxicity of IAPP (left) and, to a lesser extent, IAPP amyloids (right). Significant mitigation of toxicity in amyloids was observed when pre-treated with aLac and Lys. Scale = 25 μm; *p < 0.05 (one-way ANOVA, n = 3).
