Figure 1
From: Dysregulation of angiogenesis-specific signalling in adult testis results in xenograft degeneration
Histological examination and quantitative assessment of seminiferous tubules for the most advanced germ cell type. (A) In adult donor tissue from 10-wk-old rat (T0). Seminiferous tubule with normal spermatogenesis is indicated by an asterisk. (B) In adult rat testis xenograft at 8-wk-post grafting. Degenerated seminiferous tubules are indicated by asterisks and arrows indicate sperm. (C) In immature donor tissue from 6-day-old rat (T0). Note that the most advanced germ cells at this age were gonocytes/spermatogonia (arrows). (D) In immature rat testis xenograft at 8-wk -post grafting. Note that the most advanced germ cells identified in the xenografts were pachytene-stage spermatocytes (arrows). (E) Percentage of seminiferous tubules with the most advanced germ cell type. Deg tubules, degenerated tubules; SC, Sertoli cell only; Gon/spg, gonocytes or spermatogonia; Spcyt, pachytene spermatocytes; Rd Spd, round spermatid; Elon Spd, elongated spermatid; Spermatozoa, spermatozoa. Data are presented as mean ± SEM. Bars with different letters are significantly different at P < 0.05. Scale bar = 50 µm.
