Figure 1 | Scientific Reports

Figure 1

From: Identification of New Shikonin Derivatives as Antitumor Agents Targeting STAT3 SH2 Domain

Figure 1

(A) Reported synthetic STAT3 inhibitors and SHK with lead compound. The analogous structure for these compounds is colored in red. (B) Synthesis of compounds PMM-158~PMM-173. Reagents and conditions: (a) concentrated sulfuric acid, ethanol, reflux, 24 h; (b) NH2NH2-H2O (85%), ethanol, reflux, 12 h; (c) (1) CS2/KOH, ethanol (95%), reflux, 24 h; (2) HCl, PH 5–6; (d) ClCH2COOH, ethanol, reflux, 12 h; (e) DCC, DMAP, CH2Cl2, 0 °C, 8 h.

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