Table 2 The results of path model A.

Clinical Factor			Estimate	Standard error	Test statistic	P-Value	Standard regression coefficient
Clinical Factor			Estimate	Standard error	Test statistic	P-Value	Direct Effect	Indirect Effect	Total Effect
Vesssel Disease (R² = 0.076)	←	Age	0.006	0.003	2.342	0.019	0.074	0	0.074
	←	Gender	0.088	0.077	1.153	0.249	0.165	0	0.165
	←	BMI	−0.014	0.007	−2.057	0.040	−0.058	0	−0.058
	←	TG	−0.001	0.000	−2.319	0.020	−0.063	0	−0.063
	←	Smoking	0.058	0.037	1.573	0.116	0.043	0	0.043
	←	AO sys	0.004	0.001	3.502	<0.001	0.101	0	0.101
	←	eGFR	−0.004	0.002	−2.725	0.006	−0.086	0	−0.086
	←	HbA1c	0.161	0.026	6.142	<0.001	0.165	0	0.165
	←	UA	0.055	0.020	2.792	0.005	0.080	0	0.080
LVEF (R² = 0.146)	←	Age	0.176	0.032	5.500	<0.001	0.183	−0.016	0.166
	←	Gender	0.088	0.885	−1.887	0.059	−0.055	−0.007	−0.062
	←	BMI	−0.014	0.080	3.887	<0.001	0.114	0.013	0.127
	←	TG	−0.001	0.003	2.502	0.012	0.071	0.014	0.085
	←	Smoking	−0.810	0.429	−1.889	0.059	−0.054	−0.009	−0.063
	←	AO sys	0.057	0.012	4.548	<0.001	0.131	−0.022	0.109
	←	eGFR	0.107	0.018	5.935	<0.001	0.195	0.019	0.214
	←	HbA1c	−1.056	0.305	−3.458	<0.001	−0.098	−0.036	−0.134
	←	UA	−0.652	0.227	−2.868	0.004	−0.086	−0.018	−0.103
	←	Vessel Disease	−2.417	0.306	−7.797	<0.001	−0.219.	0	−0.219

The results (direct, indirect, and total effects) of the path model theoretically proposed analysis to identify the clinical factors influencing between each other (see Fig. 1). RMSEA 0.128, AIC 154.0.
R²: squared multiple correlations.
BMI, body mass index; TG, triglycerides; AO sys, Systolic blood pressure in the Aorta; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c; UA, uric acid; LVEF, left ventricular ejection fraction.

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