Table 3 Other polymorphisms in pfcrt and pfmdr1.

From: High throughput resistance profiling of Plasmodium falciparum infections based on custom dual indexing and Illumina next generation sequencing-technology

 

Base position

Codon position

Reference base

Alternative base

Reference codon

Alternative codon

Reference freq.

Alternative freq.

Mixed freq.

Non-synonymous polymorphisms

pfcrt

382

128

T

A

L

I

99.4%

1.3%

0.6%

pfmdr1

35

12

A

C

N

T

99.4%

0.6%

0.0%

2903

968

G

T

G

V

99.7%

0.3%

0.0%

3597

1199

T

G

N

K

95.0%

7.8%

2.8%

Synonymous polymorphisms

pfmdr1

306

102

T

C

G

G

96.3%

5.6%

1.9%

447

149

T

G

S

S

97.8%

2.2%

0.0%

3186

1062

C

T

D

D

99.7%

0.3%

0.0%

3207

1069

T

G

T

T

94.8%

7.2%

2.0%

3411

1137

A

C

Y

Y

98.8%

1.6%

0.3%

3417

1139

A

G

P

P

99.7%

0.6%

0.3%

  1. The table describes polymorphisms identified amongst the 318 resistance-profiled samples in pfcrt and pfmdr1 other than the positions of interest indicated on Fig. 3 and Table 2. The frequencies of both the reference and alternative are listed, as well as the frequency of mixed infections. Note that mixed infections were counted in both the reference and alternative frequencies.
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