Table 2 Univariate analysis of possible risk factors associated with the development of Grade ≥2 RP.

From: Pulmonary emphysema is a risk factor for radiation pneumonitis in NSCLC patients with squamous cell carcinoma after thoracic radiation therapy

Risk factors

 

Non-small cell lung cancer (n = 153)

Non-squamous cell carcinoma (n = 60)

Squamous cell carcinoma (n = 93)

RP<G2 (n%)

RP ≥G2 (n%)

P-value

RP<G2 (n%)

RP ≥G2 (n%)

P-value

RP<G2 (n%)

RP ≥G2 (n%)

P-value

Gender

Male

110

30

>0.999

38

11

>0.999

72

19

>0.999

Female

10

3

 

8

3

 

2

0

 

Age

 

62.19 ± 8.89

65.70 ± 9.58

0.050

63.26 ± 9.31

63.71 ± 10.29

0.613

61.53 ± 8.62

67.16 ± 9.02

0.014

Tumor location

Upper

67

20

0.656

23

7

0.703

44

13

0.736

Middle

22

7

 

9

4

 

13

3

 

Lower

31

6

 

14

3

 

17

3

 

Smoking history

Yes

75

19

0.607

25

6

0.451

50

13

0.943

No

45

14

 

21

8

 

24

6

 

chemotherapy

Concurrent

20

2

0.248

9

0

0.059

11

2

0.424

Sequence 1a

94

29

 

34

12

 

60

17

 

Sequence 2b

6

2

 

3

2

 

3

0

 

PE Grade

0

73

12

0.012

29

8

0.162

44

4

<0.001

1

34

11

 

12

6

 

22

5

 

≥2

13

10

 

5

0

 

8

10

 

FEV1/FVC%

≥70

56

15

0.902

22

8

0.542

34

7

0.476

<70

64

18

 

24

6

 

40

12

 

FVC

≥2.8

67

11

0.022

22

6

0.744

45

5

0.007

<2.8

53

22

 

24

8

 

29

14

 

PO2

 

84.13 ± 11.85

81.42 ± 9.07

0.225

81.43 ± 13.40

84.00 ± 7.92

0.085

85.81 ± 10.54

79.53 ± 9.58

0.020

PCO2

 

37.49 ± 4.09

36.93 ± 4.51

0.497

37.33 ± 4.03

36.87 ± 4.67

0.813

37.59 ± 4.15

36.98 ± 4.52

0.573

V5

 

49.14 ± 7.64

50.52 ± 7.51

0.360

49.28 ± 7.44

50.36 ± 8.46

0.680

49.05 ± 7.81

50.63 ± 6.96

0.425

V20

 

22.16 ± 3.96

23.55 ± 3.96

0.077

21.93 ± 3.99

23.50 ± 4.36

0.565

22.30 ± 3.97

23.58 ± 3.76

0.208

MLD

 

11.88 ± 2.61

12.69 ± 2.67

0.118

11.96 ± 2.60

12.47 ± 3.21

0.210

11.83 ± 2.63

12.85 ± 2.27

0.125

  1. RP: radiation pneumonitis; G2, grade 2; G3, grade 3; PE, pulmonary emphysema; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; PO2, arterial partial pressure of oxygen; PCO2, arterial partial pressure of carbon dioxide; V5, V20, the percentages of pulmonary volume irradiation exceeding 5 Gy, 20 Gy; MLD, mean lung dose. aSequence 1, patients who received chemotherapy first. bSequence 2, patients who received radiation therapy first. Significant differences are indicated in bold.
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