Table 3 Univariate analysis of possible risk factors associated with the development of Grade ≥3 RP.

From: Pulmonary emphysema is a risk factor for radiation pneumonitis in NSCLC patients with squamous cell carcinoma after thoracic radiation therapy

Risk factors

 

Non-small cell lung cancer (n = 153)

Non-squamous cell carcinoma (n = 60)

Squamous cell carcinoma (n = 93)

RP <G3 (n%)

RP ≥G3 (n%)

P-value

RP <G3 (n%)

RP ≥G3 (n%)

P-value

RP <G3 (n%)

RP ≥G3 (n%)

P-value

Gender

Male

125

15

>0.999

44

5

>0.999

81

10

>0.999

Female

12

1

 

10

1

 

2

0

 

Age

 

62.29 ± 8.90

68.56 ± 9.46

0.009

62.76 ± 9.52

68.83 ± 7.36

0.307

61.99 ± 8.51

68.40 ± 10.91

0.032

Tumor location

Upper

77

10

0.847

27

3

0.692

50

7

0.765

Middle

26

3

 

11

2

 

15

1

 

Lower

34

3

 

16

1

 

18

2

 

Smoking history

Yes

84

10

0.927

28

3

>0.999

56

7

>0.999

No

53

6

 

26

3

 

27

3

 

Chemotherapy

Concurrent

21

1

0.559

9

0

0.304

12

1

0.641

Sequence 1a

109

14

 

41

5

 

68

9

 

Sequence 2b

7

1

 

4

1

 

3

0

 

PE Grade

0

82

3

0.006

35

2

0.112

47

1

0.007

1

37

8

 

14

4

 

23

4

 

≥2

18

5

 

5

0

 

13

5

 

FEV1/FVC %

≥70

65

6

0.450

27

3

>0.999

38

3

0.540

<70

72

10

 

27

3

 

45

7

 

FVC

≥2.8

72

6

0.254

25

3

>0.999

47

3

0.208

<2.8

65

10

 

29

3

 

36

7

 

PO2

 

83.97 ± 11.71

79.94 ± 6.72

0.179

82.19 ± 12.86

80.67 ± 6.19

0.307

85.13 ± 10.81

79.50 ± 7.31

0.113

PCO2

 

37.54 ± 4.27

35.98 ± 3.05

0.158

37.38 ± 4.26

35.82 ± 2.89

0.103

37.64 ± 4.30

36.07 ± 3.30

0.269

V5

 

49.25 ± 7.75

51.06 ± 6.17

0.368

49.37 ± 8.02

51.00 ± 1.10

0.010

49.17 ± 7.62

51.10 ± 7.92

0.453

V20

 

22.27 ± 3.98

24.06 ± 3.84

0.089

22.11 ± 4.12

24.00 ± 3.74

0.562

22.37 ± 3.91

24.10 ± 4.09

0.192

MLD

 

11.93 ± 2.64

13.09 ± 2.39

0.098

12.07 ± 2.78

12.17 ± 2.49

0.882

11.85 ± 2.56

13.64 ± 2.27

0.037

  1. RP: radiation pneumonitis; G2, grade 2; G3, grade 3; PE, pulmonary emphysema; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; PO2, arterial partial pressure of oxygen; PCO2, arterial partial pressure of carbon dioxide; V5, V20, the percentages of pulmonary volume irradiation exceeding 5 Gy, 20 Gy; MLD, mean lung dose. aSequence 1, patients who received chemotherapy first. bSequence 2, patients who received radiation therapy first. Significant differences are indicated in bold.
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