Figure 7 | Scientific Reports

Figure 7

From: Chronic low-dose exposure to a mixture of environmental endocrine disruptors induces microRNAs/isomiRs deregulation in mouse concomitant with intratesticular estradiol reduction

Figure 7

Down-regulation of miR-18a-5p in mice exposed to EDCs mixture is associated with estradiol decrease in testes via Nr1h2. (A) Prediction of Nr1h2 as a target of miR-18a-5p, (B) mRNA expression of Nr1h2 and miR-18a-5p in the testes of mice exposed to EDCs mixture versus control mice by RT-qPCR, fold change (log2) ± SEM, n = 4, and Nr1h2:miR-18a-5p Spearman’s rank correlation coefficient (Spearman’s rho), *p < 0.05. Abbreviation: AU, arbitrary units. (C) Role of miR-18a-5p in the estradiol decrease in the testes of mice exposed to EDCs mixture (proposed model). Red arrow = up-regulated, green arrow = down-regulated.

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