Figure 1 | Scientific Reports

Figure 1

From: MicroRNA-34a Encapsulated in Hyaluronic Acid Nanoparticles Induces Epigenetic Changes with Altered Mitochondrial Bioenergetics and Apoptosis in Non-Small-Cell Lung Cancer Cells

Figure 1

Characteristics of miR34a hyaluronic acid (HA)-based nanoparticles. (A) Schematic representation of HA-PEI/HA-PEG nano-assemblies encapsulated with miR34a duplexes. (B) The self-assembling miR34a HA-NPs nanoparticles showed a spherical morphology in TEM. (C–F) Flow cytometry analysis indicated that the miR34a HA-NPs were taken up by the A549 cells and cisplatin resistant A549 cells (A549 DDP) cells in a time dependent manner. The HA-PEI was conjugated with rhodamine dye and the miR34a was conjugated with FITC. (G,H) Confocal images to support the flow cytometry results indicating the uptake of the FITC-miR34a encapsulated in HAPEI nanovectors; mitochondria stained by MitoTrackr™.

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