Figure 3 | Scientific Reports

Figure 3

From: Characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling by integrative analysis of transcriptomic and proteomic data

Figure 3

TSC-implicated cellular processes affected by hyperactivated mTOR signaling. (A) The overall scheme of integrative analysis of DEGs and DEPs by hyperactivated mTOR signaling and DEGs identified from transcriptomic data of TSC patients (GSE16969 and GSE62019). GOBPs represented by DEGs and DEPs by hyperactivated mTOR signaling and DEGs identified from TSC transcriptomic data were integrated. (B,C) Relationships among DEGs and DEPs by hyperactivated mTOR signaling and DEGs identified from GSE16969 and GSE62019. Venn diagrams were separately made for up- (B) and down-regulated (C) genes or proteins. D, GOBPs represented by the following eight sets of genes and proteins: 1–4) up- (DEGs_up and DEPs_up) and down-regulated (DEGs_down and DEPs_down) genes and proteins by hyperactivated mTOR signaling and 5–8) up- (GSE16969_up and GSE62019_up) and down-regulated (GSE16969_down and GSE62019_down) genes in the two transcriptomic datasets. The significance of GOBPs being enriched by the indicated sets of genes or proteins was displayed by –log10(P) where P is the enrichment P-value obtained from DAVID software. The color bar denotes gradients of –log10(P).

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