Figure 4 | Scientific Reports

Figure 4

From: E. coli promotes human Vγ9Vδ2 T cell transition from cytokine-producing bactericidal effectors to professional phagocytic killers in a TCR-dependent manner

Figure 4

γδT cell acquisition of phagocytic capacity is concurrent with sustained upregulation of cell surface HLA-DR and CD86, but not CCR7. Freshly-isolated PBMC (n = 5) were expanded for 14 days with irradiated E. coli, and stained for cell surface HLA-DR, CD86 and CCR7 throughout expansion. (A) Representative stains of one donor γδT cells is shown, with specific antibody in black, unshaded, and isotype-matched control - in gray, shaded. (B) HLA-DR, CD86 (left column) and CCR7 (right column) MFI over expansion was compared between γδT, αβT cells and monocytes (CD3negCD14pos PBMC).

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