Table 1 Pharmacokinetic parameters of empagliflozin (EG) following oral administration of one JARDIANCE tablet nominally containing 25 mg of EG.

From: Pharmacokinetic Evaluation of Empagliflozin in Healthy Egyptian Volunteers Using LC-MS/MS and Comparison with Other Ethnic Populations

Pharmacokinetic parameters

Empagliflozin

Cmax (nMol/L), Mean ± S.D. (% C.V.)

576 ± 86 (14.93)

Tmax (hours), Median (range)

1.5, (1–2)

t 1/2 (hours), Mean ± S.D. (% C.V.)

6.1 ± 1.2 (19.67)

Elimination rate constant (h−1), Mean ± S.D. (% C.V.)

0.10012 ± 0.02156 (19.25)

AUC0−t (12) (nMol.h/L), Mean ± S.D. (% C.V.)

2806 ± 234 (8.34)

AUC0-inf (nMol.h/L), Mean ± S.D. (% C.V.)

4103 ± 427 (10.41)

  1. Abbreviations: AUC = area under the curve; % C.V. = percent coefficient of variation; S.D. = standard deviation.