Figure 5 | Scientific Reports

Figure 5

From: β-lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in NQO1-positive breast cancers

Figure 5

β-lapachone suppressed EMT progression in breast cancer cells in vitro. (A) The changes in the protein expression levels of the epithelial marker E-cadherin and the mesenchymal markers Vimentin, Snail, Slug, Twist, and MMP-9 in MCF-7 and MDA-MB-231 cells treated with DMSO or 4 μM β-lap for 48 h. (B) IF staining for the E-cadherin, Vimentin, and MMP-9 proteins in the two groups of MCF-7 and MDA-MB-231 cells treated with 4 μM β-lap. (C) The changes in the protein expression levels of the epithelial marker E-cadherin and the mesenchymal markers Vimentin, snail in si-NQO1-transfected MCF-7 and MDA-MB-231 cells treated with 4 μM β-lapachone for 48 h. **P < 0.01 is based on the Student t test. All results are from three independent experiments. Error bars, SD.

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