Table 3 Parameter estimates for pneumococcus transmission and PCV7 vaccine efficacy (VE) in day care settings.

From: Geographic variation in pneumococcal vaccine efficacy estimated from dynamic modeling of epidemiological data post-PCV7

Country

Basic reproduction number R 0

Competition parameter k

Vaccine efficacy VE

Transmission rate β (month−1)

Portugal

3.18 (2.87, 3.53)

0.08 (0.06, 0.11)

0.11 (0.09, 0.14)

2.36 (2.13, 2.62)

Norway

4.77 (4.28, 5.30)

0.04 (0.03, 0.05)

0.43 (0.35, 0.50)

3.49 (3.13, 3.88)

France

2.22 (2.14, 2.31)

—

0.19 (0.16, 0.21)

1.68 (1.62, 1.74)

Greece

1.85 (1.79, 1.91)

0.045 (0.04, 0.05)

0.21 (0.17, 0.25)

1.36 (1.32, 1.41)

Hungary

1.55 (1.49, 1.62)

—

0.27 (0.20, 0.31)

1.17 (1.12, 1.22)

Hong Kong

1.23 (1.22, 1.24)

—

0.08 (0.05, 0.10)

0.91 (0.90, 0.92)

  1. The means and the 95% credible intervals for each parameter are obtained from the posterior distributions. The competition coefficient k is estimated from co-colonization data in some cases, and set to a fixed value in others (—), equal to 0.05, a criterion used to calibrate model initial conditions (see Methods 2). The basic reproduction number is derived as: \({R}_{0}(i)=\frac{\beta (i)}{\gamma +\mu (i)}\). Setting-specific birth/death rate μ for the SIS model was assumed as the inverse of mean duration of DCC attendance for children in each study (see Table S2 for results based on 1/mean age instead).
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