Table 2 Eight drugs used for intestinal diseases. The drug names of 5-Fluorouracil and Hydrocortisone could not be searched in database, the synonyms of these drugs were provided.
From: TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations
Drug name | Synonym | Related diseases | Candidate related genes |
|---|---|---|---|
Hydrocortisone | Cortisol | Inflammatory disease | CRH, CYP19A1, HSD11B1, POMC, SERPINA6 |
5-Fluorouracil | 5-FU | Colorectal cancer and breast cancer | ABCC5, CASP3, CASP8, CYP2C9, DHFR, DPYD, TP53, TYMP, TYMS |
Leucovorin | / | Colorectal cancer | ABCC2, MTHFS, RFC1, SHMT1 |
Regorafenib | / | Gastrointestinal stromal tumors | BRAF, FLT1, KDR, KIT, PDGFRA |
Capecitabine | / | Colorectal cancer and breast cancer | CDA, CYP2C9, CYR61, DPYD, HIF1A, HRAS, TYMS |
Sulfasalazine | / | Inflammatory bowel disease | ABCG2, IL1B, MPO, NAT2, NFKBIA, PTGS2 |
Prednisone | / | Inflammatory disease, some autoimmune diseases and some types of cancer | ALB, CRP, CYP3A4, HLA-A, HLA-C, NR3C1 |
Oxaliplatin | / | Colon cancer | BIRC5, CASP3, CCND1, ERCC1, GSTP1, PARP1, VEGFA |
