Figure 3 | Scientific Reports

Figure 3

From: Knee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric MRI and micro-CT in experimental CKD

Figure 3

Plots showing the time courses of three perfusion parameters and the MRI T2* values (mean ± SD) for the femoral and tibial subchondral bone marrow (SCBM) of the control and CKD groups. (a) Amplitude A (unit: au). (b) Elimination constant k el (unit: min−1). (c) Permeability rate constant k ep (unit: min−1). (d) T2* (unit: msec). All values were measured in the right knees of all rats. Asterisks demonstrated significant differences (p < 0.05). A significant increase in the blood volume parameter A and washout parameter k el can be observed in (a) and (b) at week 0, and was followed by a decrease beginning at week 8. Significant increases can be noted in the permeability rate constant k ep (c) starting from week 36 and in MRI T2* value (i.e., edematous change) (d) starting from week 16.

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