Table 1 Fifteen novel genome wide associated loci for coronary artery disease. Data presented here is from the meta-analysis; full summary statistics are available in supplementary Table 3.

From: Identification of 15 novel risk loci for coronary artery disease and genetic risk of recurrent events, atrial fibrillation and heart failure

Region

Genetic variant

EA/NEA

EAF

OR (95% CI)

P Value

Gene

1q21.3

rs11810571

G/C

0.787

1.069 (1.05-1.09)

1.72 × 10−10

TDRKHn,e

3p21.31

rs7623687

A/C

0.859

1.069 (1.04-1.09)

3.28 × 10−08

RHOAn, AMTn, TCTAn, CDHR4c, KLHDC8Bd

3q21.2

rs142695226

G/T

0.136

1.078 (1.05-1.10)

1.70 × 10−10

UMPSn,e, ITGB5n,d

3q25.2

rs433903

G/A

0.857

1.081 (1.06-1.11)

6.06 × 10−10

SGEF(Arhgef26)n, DHX36e

4q21.21

rs10857147

T/A

0.269

1.061 (1.04-1.08)

4.29 × 10−10

PRDM8n, FGF5n

4q27

rs11723436

G/A

0.305

1.053 (1.04-1.07)

7.01 × 10−09

MAD2L1n, PDE5Ae

4q31.21

rs35879803

C/A

0.702

1.051 (1.03-1.07)

3.83 × 10−08

ZNF827n,e

6p22.3

rs35541991

C/CA

0.312

1.049 (1.03-1.07)

2.57 × 10−08

HDGFL1n

11p15.2

rs1351525

T/A

0.674

1.049 (1.03-1.07)

4.09 × 10−08

ARNTLn,c,e

12q13.13

rs11170820

G/C

0.076

1.098 (1.06-1.13)

4.09 × 10−08

HOXC4n

12q24.31

rs2244608

G/A

0.349

1.056 (1.04-1.07)

1.86 × 10−10

HNF1Anc, OASLd

14q24.3

rs3832966

I/D

0.458

1.054 (1.04-1.07)

5.80 × 10−10

TMED10n,e, ZC2HC1Ce, RPS6KL1e, NEK9e, EIF2B2e, ACYP1e

16q23.1

rs33928862

D/I

0.506

1.049 (1.03-1.07)

2.47 × 10−08

BCAR1n,e,d

16q23.3

rs7500448

A/G

0.772

1.069 (1.05-1.09)

4.83 × 10−11

CDH13n,e,d

19q13.2

rs138120077

D/I

0.140

1.072 (1.05-1.10)

9.44 × 10−09

HNRNPUL1n,e, TGFB1e,d, CCDC97e

19q13.2

rs8108632*

T/A

0.484

1.052 (1.03-1.07)

9.54 × 10−09

TGFB1n,d, B9D2n

  1. Abbreviations: EA = effect allele, NEA = Non-effect allele,, EAF = effect allele frequency, OR = Odds Ratio, CI = confidence interval, I = Indel, D = Deletion. Candidate gene superscripts indicate the method of identification (n = nearest gene, c = coding gene, d = depict gene, e = eQTL gene). *Denotes the secondary signal in locus of region 19q13.2.