Table 1 Fifteen novel genome wide associated loci for coronary artery disease. Data presented here is from the meta-analysis; full summary statistics are available in supplementary Table 3.
Region | Genetic variant | EA/NEA | EAF | OR (95% CI) | P Value | Gene |
---|---|---|---|---|---|---|
1q21.3 | rs11810571 | G/C | 0.787 | 1.069 (1.05-1.09) | 1.72 × 10−10 | TDRKHn,e |
3p21.31 | rs7623687 | A/C | 0.859 | 1.069 (1.04-1.09) | 3.28 × 10−08 | RHOAn, AMTn, TCTAn, CDHR4c, KLHDC8Bd |
3q21.2 | rs142695226 | G/T | 0.136 | 1.078 (1.05-1.10) | 1.70 × 10−10 | UMPSn,e, ITGB5n,d |
3q25.2 | rs433903 | G/A | 0.857 | 1.081 (1.06-1.11) | 6.06 × 10−10 | SGEF(Arhgef26)n, DHX36e |
4q21.21 | rs10857147 | T/A | 0.269 | 1.061 (1.04-1.08) | 4.29 × 10−10 | PRDM8n, FGF5n |
4q27 | rs11723436 | G/A | 0.305 | 1.053 (1.04-1.07) | 7.01 × 10−09 | MAD2L1n, PDE5Ae |
4q31.21 | rs35879803 | C/A | 0.702 | 1.051 (1.03-1.07) | 3.83 × 10−08 | ZNF827n,e |
6p22.3 | rs35541991 | C/CA | 0.312 | 1.049 (1.03-1.07) | 2.57 × 10−08 | HDGFL1n |
11p15.2 | rs1351525 | T/A | 0.674 | 1.049 (1.03-1.07) | 4.09 × 10−08 | ARNTLn,c,e |
12q13.13 | rs11170820 | G/C | 0.076 | 1.098 (1.06-1.13) | 4.09 × 10−08 | HOXC4n |
12q24.31 | rs2244608 | G/A | 0.349 | 1.056 (1.04-1.07) | 1.86 × 10−10 | HNF1Anc, OASLd |
14q24.3 | rs3832966 | I/D | 0.458 | 1.054 (1.04-1.07) | 5.80 × 10−10 | TMED10n,e, ZC2HC1Ce, RPS6KL1e, NEK9e, EIF2B2e, ACYP1e |
16q23.1 | rs33928862 | D/I | 0.506 | 1.049 (1.03-1.07) | 2.47 × 10−08 | BCAR1n,e,d |
16q23.3 | rs7500448 | A/G | 0.772 | 1.069 (1.05-1.09) | 4.83 × 10−11 | CDH13n,e,d |
19q13.2 | rs138120077 | D/I | 0.140 | 1.072 (1.05-1.10) | 9.44 × 10−09 | HNRNPUL1n,e, TGFB1e,d, CCDC97e |
19q13.2 | rs8108632* | T/A | 0.484 | 1.052 (1.03-1.07) | 9.54 × 10−09 | TGFB1n,d, B9D2n |