Table 3 Cox survival model predicting hazard of death using the genetic risk score based on the 71 genome wide significant CAD variants.

From: Identification of 15 novel risk loci for coronary artery disease and genetic risk of recurrent events, atrial fibrillation and heart failure

Phenotype

N deaths (%)

Hazard Ratio (95% CI)

P value

Coronary Artery Disease

723 (0.5%)

1.75 (1.48 to 2.08)

4.90 × 10−11

Myocardial Infarction

210 (0.1%)

1.93 (1.41 to 2.63)

3.40 × 10−05

Heart failure

219 (0.2%)

1.39 (1.02 to 1.88)

3.69 × 10−02

Cardiomyopathy

40 (0.0%)

1.18 (0.58 to 2.40)

6.48 × 10−01

Cerebral Infarction and TIA

124 (0.1%)

1.32 (0.87 to 1.98)

1.89 × 10−01

All cause mortality

4373 (3.0%)

1.02 (0.95 to 1.09)

5.65 × 10−01

Cardiovascular mortality (as primary cause of death)

892 (0.6%)

1.46 (1.26 to 1.70)

9.08 × 10−07

  1. Abbreviations: N = Number, CI = Confidence Interval, TIA = Transient Ischemic Attack.
Back to article page