Table 4 Heritability estimates for cardiovascular traits and the shared heritability between each trait and CAD in all UK Biobank Participants based on common genetic variation under the additive model (h ² _g ). For dichotomous traits, the heritability on the observed 0-1 scale was transformed to h ² _g on the unobserved continuous liability scale by a linear transformation.

Body-mass index

0.316 (0.005)

0

0.289 (0.026)

3.67 × 10⁻²⁸

 Height

0.614 (0.004)

0

−0.142 (0.019)

5.93 × 10⁻¹³

 Resting heart rate

0.204 (0.005)

0

0.099 (0.033)

4.64 × 10⁻⁰³

Blood pressure

 Systolic

0.198 (0.005)

0

0.380 (0.034)

8.04 × 10⁻²⁹

 Diastolic

0.197 (0.005)

0

0.316 (0.034)

3.15 × 10⁻²⁰

 Pulse pressure

0.220 (0.005)

0

0.265 (0.030)

8.08 × 10⁻¹⁸

 Mean arterial pressure

0.191 (0.005)

0

0.380 (0.035)

3.70 × 10⁻²⁷

 Arterial stiffness index

0.082 (0.012)

2.13 × 10⁻¹¹

0.075 (0.118)

3.26 × 10⁻⁰¹

 Smoking current

0.238 (0.012)

3.06 × 10⁻⁸⁷

0.258 (0.043)

8.30 × 10⁻⁰⁹

 Coronary Artery Disease

0.216 (0.016)

8.77 × 10⁻⁴²

—

—

 Hypertension

0.310 (0.008)

0

0.577 (0.031)

1.39 × 10⁻⁷⁵

 Diabetes

0.345 (0.017)

2.90 × 10⁻⁹⁵

0.412 (0.041)

2.88 × 10⁻²³

 Myocardial Infarction

0.190 (0.025)

4.21 × 10⁻¹⁴

1.000 (0.035)

2.40 × 10⁻¹⁷⁴

 Heart failure

0.098 (0.044)

3.49 × 10⁻⁰²

0.679 (0.158)

4.04 × 10⁻⁰⁵

 Cardiomyopathy

0.071 (0.134)

3.47 × 10⁻⁰¹

0.462 (0.483)

2.53 × 10⁻⁰¹

 Atrial fibrillation/flutter

0.238 (0.025)

1.92 × 10⁻²¹

0.323 (0.058)

8.29 × 10⁻⁰⁸

 Cerebral Infarction and TIA

0.090 (0.028)

2.62 × 10⁻⁰³

0.635 (0.134)

4.93 × 10⁻⁰⁶

 Device implantation

0.074 (0.055)

1.61 × 10⁻⁰¹

0.678 (0.261)

1.36 × 10⁻⁰²

 Beta-blockers

0.156 (0.016)

1.94 × 10⁻²²

0.818 (0.053)

6.26 × 10⁻⁵³

 Calcium channel-blockers

0.251 (0.016)

6.41 × 10⁻⁵⁵

0.547 (0.049)

2.76 × 10⁻²⁸