Table 2 Time dependent inhibition of dimethylarginine dimethylaminohydrolase 1 by proton pump inhibitors represented as percent residual activity.

From: Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance

PPI

30 min

60 min

120 min

180 min

240 min

P-value*

Esomeprazole

89 ± 10

86 ± 2

82 ± 10

79 ± 6

75 ± 9

0.253

Lansoprazole

93 ± 1

78 ± 14

71 ± 6

63 ± 8

66 ± 1

0.034

Omeprazole

87 ± 8

91 ± 20

78 ± 6

77 ± 4

76 ± 3

0.367

Pantoprazole

90 ± 10

89 ± 14

92 ± 13

92 ± 8

86 ± 7

0.959

Rabeprazole

56 ± 7

43 ± 5

31 ± 3

26 ± 6

25 ± 4

<0.001

  1. Residual dimethylarginine dimethylaminohydrolase 1 activity (expressed as percentage of the control) following different pre-incubation times for each proton pump inhibitor. Each value represents the mean of three experiments ± SD. Experiments were performed with a proton pump inhibitor concentration of 60 µmol/L. PPI: proton pump inhibitor; *: for trend.
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