Table 1 Differential metabolite profiles during myopia development.

From: Changes in retinal metabolic profiles associated with form deprivation myopia development in guinea pigs

Compound

FD3d versus NC3d

FD2w versus NC2w

p value

FC

VIP

FC

VIP

T/C

T/F

T vs C

F VS T

T/C

T/F

T vs C

F VS T

T vs C

Mannose

2.69

0.50

2.29

1.21

1.95

1.26

0.70

0.49

0.060

Urea

0.69

0.85

2.22

1.40

0.86

1.00

1.00

0.00

0.012

Glucose

1.37

0.82

1.93

1.18

1.31

0.98

1.22

0.19

0.012

Arabinose

0.45

0.85

1.44

1.45

0.92

0.88

0.31

1.04

0.148

Tyrosine

0.86

0.72

1.00

1.63

0.91

0.87

0.52

1.13

0.096

Glutamic acid

0.90

0.85

1.03

1.31

0.91

0.99

0.82

0.12

0.112

Threonine

0.79

0.78

2.00

1.48

0.86

0.87

0.95

1.17

0.013

Valine

0.87

0.80

2.05

1.81

0.85

0.83

1.16

1.86

0.011

Isoleucine

0.85

0.78

1.98

1.90

0.81

0.81

1.38

2.02

0.010

Malic acid

0.85

0.93

1.38

0.62

0.78

0.88

1.38

1.15

0.012

Alanine

0.94

0.84

1.04

1.67

0.87

0.85

1.15

1.72

0.032

Arachidic acid (20:0)

0.93

1.04

0.26

0.14

0.26

0.66

2.20

1.94

0.010

Octadecenoic acid (18:1)

0.96

0.93

0.45

0.52

0.73

0.94

2.02

1.29

0.010

Octadecanoic acid (18:0)

1.03

0.94

0.43

0.52

0.82

0.92

1.84

1.38

0.041

Arachidonic acid (20:4)

0.96

0.96

0.54

0.38

0.80

0.94

1.78

1.94

0.014

Cholesterol

0.98

0.93

0.43

0.67

0.80

0.92

1.72

1.39

0.012

Ethanolamine

1.08

0.95

0.38

0.29

0.79

0.85

1.66

2.13

0.179

Hexadecanoic acid (16:0)

1.04

0.90

0.66

0.79

0.80

0.93

1.61

1.12

0.042

Tetradecanoic acid (14:0)

0.91

0.93

0.90

0.57

0.71

0.87

1.59

1.25

0.013

Octadecadienoic acid (18:2)

0.90

0.90

0.57

0.52

0.66

1.19

1.43

1.23

0.031

2-Ketoglutaric acid

1.51

0.69

0.84

1.28

2.61

0.68

1.09

1.33

0.047

GABA

0.98

0.89

0.33

1.21

0.87

0.93

1.08

1.10

0.090

  1. FC: fold change, abundance of individual metabolites in the former versus the latter group. T: FD eyes; F: fellow eyes; C: normal control eyes. VIP: variable importance in the OPLS model discriminating two groups. P values are from two-way ANOVA assessing main effect of treatment type (with or without FD), adjusted by FDR method with q value set at 0.05. Compound changes with VIP > 1.0 and P < 0.05(shown in italic bold) were regarded as significant. The five listed boldface compounds were significantly different in both FD3d versus NC3d and FD2w versus NC2w. Except for them, the first 6 compounds in the table were significantly different in FD3d versus NC3d and the bottom 11were significantly different in FD2w versus NC2w.
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